000			02780nam a2200325 4500
001			ESSALUD
005			20260819164758.0
007			ta
008			t pe ||||| |||| 00| 0 spa d
040			_aBMG
041			_aeng
100			_aFrat, Jean-Pierre _eAutor _954172
245			_aHigh-flow or standard oxygen in acute hypoxemic respiratory failure
300			_apáginas: 2095-2106
520			_aBackground: Data are needed on the effect of oxygen delivered through a high-flow nasal cannula, as compared with standard oxygen therapy, on intubation and mortality in patients with acute hypoxemic respiratory failure. Methods: In this multicenter, open-label trial, we randomly assigned patients who had acute hypoxemic respiratory failure to receive high-flow-oxygen or standard-oxygen therapy. All the patients had a ratio of the partial pressure of arterial oxygen to the fraction of inspired oxygen of 200 or less, a respiratory rate of more than 25 breaths per minute, and pulmonary infiltrate on chest imaging. The primary outcome was death by day 28. Results: A total of 1116 patients underwent randomization. Of these patients, 1110 (556 in the high-flow-oxygen group and 554 in the standard-oxygen group) were included in the analysis. Mortality at day 28 was 14.6% (in 81 of 556 patients) in the high-flow-oxygen group and 14.6% (in 81 of 554 patients) in the standard-oxygen group (difference, −0.05 percentage points; 95% confidence interval [CI], −4.21 to 4.10; P=0.98). The incidence of intubation by day 28 was 42.4% (in 236 of 556 patients) in the high-flow-oxygen group and 48.4% (in 268 of 554 patients) in the standard-oxygen group (difference, −5.93 percentage points; 95% CI, −11.78 to −0.08). Serious adverse events (cardiac arrest or pneumothorax) occurred during spontaneous breathing in 13 patients (2.3%) in the high-flow-oxygen group and in 6 patients (1.1%) in the standard-oxygen group. Conclusions: Among patients with acute hypoxemic respiratory failure, the use of oxygen delivered through a high-flow nasal cannula did not significantly reduce mortality at day 28.
650			_aCUIDADOS INTENSIVOS _95208
650			_aMEDICINA DE URGENCIAS _953820
650			_aMEDICINA CLINICA HOSPITALARIA _953754
650			_aVENTILACION MECANICA _937360
650			_aNEUMOLOGÍA _925628
700			_aQuenot, Jean-Pierre _954173
700			_aGuitton, Christophe _954174
700			_aCoudroy, Rémi _954175
700			_aGacouin, Arnaud _954176
700			_aBadie, Julio _954177
700			_aDemoule, Alexandre _954178
700			_aContou, Damien _954179
773	0		_022717 _922648 _dMassachusetts NEJM Group _oNEJM011 _tThe New England Journal of Medicine _wESSALUD _x0028-4793
942			_cARTICULOS _e2026-08-19 _zsqb
999			_c22834 _d22834