01871nam a2200289   4500001000800000005001700008007000300025008004100028040000800069041000800077100002800085245002800113300002500141520098500166650001801151650003301169650003301202650003501235650001701270650003401287650003601321650003401357700003201391773011001423942003101533999001701564ESSALUD20260902161515.0ta      t        pe ||||| |||| 00| 0 spa d  aBMG  aeng  aAllenbach, Yves 954482  aInflammatory myopathies  apáginas: 1925-1938  aInflammatory myopathies are a heterogeneous group of autoimmune diseases characterized by immune-mediated damage to skeletal muscle. They are classified into five major subtypes: inclusion-body myositis, immune-mediated necrotizing myopathies, antisynthetase syndrome, overlapping myositis, and dermatomyositis, each with distinct clinical features and outcomes. Inclusion-body myositis and immune-mediated necrotizing myopathies primarily affect muscle, with prognosis largely determined by functional impairment, whereas antisynthetase syndrome, overlapping myositis, and dermatomyositis are systemic diseases that can involve the skin, joints, and lungs and may be life-threatening. The majority of inflammatory myopathies are associated with myositis-specific autoantibodies, which inform diagnosis, subtype classification, and prognosis. Advances in understanding the distinct pathomechanisms underlying each subgroup now enable increasingly targeted therapeutic approaches.
  aALERGIA97055  aINMUNOLOGÍA GENERAL953664  aENFERMEDAD AUTOINMUNE953665  aENFERMEDAD INFLAMATORIA953667  aNEUROLOGÍA  aNEUROCIRUGÍA GENERAL953668  aENFERMEDAD NEUROMUSCULAR953763  aREUMATOLOGÍA GENERAL954450  aBenveniste, Olivier 9544830 022717922669dMassachusetts NEJM GroupoNEJM014tThe New England Journal of Medicine wESSALUDx0028-4793  cARTICULOSe2026-08-31zsqb  c22904d22904