01714nam a2200265 4500 ESSALUD 20260902151149.0 ta t pe ||||| |||| 00| 0 spa d BMG eng Margulies, Kenneth B. Autor 54429 Patching up damaged hearts páginas: 2054-2055 Heart failure resulting from previous myocardial infarction or ischemic cardiomyopathy remains a leading cause of death and complications worldwide. The central pathophysiological processes in ischemic cardiomyopathy are the loss of myocardial tissue from necrosis after a coronary-artery occlusion, followed by replacement fibrosis that confers a disposition to heart failure and arrhythmias. Because the adult heart cannot regenerate lost myocardium, current therapies for ischemic cardiomyopathy are focused on countering maladaptive systemic neurohormonal responses that promote vasoconstriction, salt and water retention, unfavorable myocardial remodeling, and progressive heart failure. Despite these therapies, many patients have progression to advanced heart failure, for which donor shortages limit transplantation while modern, durable mechanical-support devices remain both complicated and costly. CARDIOLOGÍA GENERAL 53638 CARDIOMIOPATÍA 37409 MIOCARDITIS 38353 CIRUGÍA CARDIOVASCULAR 53947 INSUFICIENCIA CARDIACA 11699 TRASPLANTE 7847 PERICARDITIS 39732 22717 22665 Massachusetts NEJM Group NEJM013 The New England Journal of Medicine ESSALUD 0028-4793 ARTICULOS 2026-08-28 sqb 22892 22892