01429nam a2200253   4500001000800000005001700008007000300025008004100028040000800069041000800077100003900085245005800124300002300182520061300205650003800818650004300856650003000899650003600929650002400965700002900989773010901018942003101127999001701158ESSALUD20260821150043.0ta      t        pe ||||| |||| 00| 0 spa d  aBMG  aeng  aLa Vita, Carolyn J. eAutor954282  aMucolytics in respiratory failure — A MARCH forward  apáginas: 817-818  aIn patients with acute respiratory failure, difficulty managing respiratory secretions may contribute to adverse outcomes. Airway mucus is a multilayered substance consisting of a viscoelastic glycoprotein gel, a liquid layer, and a thin layer of surfactant. Mucus is cleared from the airway primarily by the action of cilia (mucociliary clearance) and interaction with airflow (cough). In acute respiratory failure, airway irritation from relatively dry inhaled gasses, infection, and inflammation can lead to mucus hypersecretion, and sedation and neuromuscular impairment can contribute to impaired cough.  aMEDICINA CLÍNICA GENERAL953666  aMEDICINA CLÍNICA HOSPITALARIA953754  aCUIDADOS INTENSIVOS95208  aVENTILACIÓN MECÁNICA937360  aNEUMOLOGÍA925628  aHardin, C. Corey 9542830 022717922650dMassachusetts NEJM GroupoNEJM12tThe New England Journal of Medicine wESSALUDx0028-4793  cARTICULOSe2026-08-21zsqb  c22858d22858