01423nam a2200253 4500 ESSALUD 20260821150043.0 ta t pe ||||| |||| 00| 0 spa d BMG eng La Vita, Carolyn J. Autor 54282 Mucolytics in respiratory failure — A MARCH forward páginas: 817-818 In patients with acute respiratory failure, difficulty managing respiratory secretions may contribute to adverse outcomes. Airway mucus is a multilayered substance consisting of a viscoelastic glycoprotein gel, a liquid layer, and a thin layer of surfactant. Mucus is cleared from the airway primarily by the action of cilia (mucociliary clearance) and interaction with airflow (cough). In acute respiratory failure, airway irritation from relatively dry inhaled gasses, infection, and inflammation can lead to mucus hypersecretion, and sedation and neuromuscular impairment can contribute to impaired cough. MEDICINA CLÍNICA GENERAL 53666 MEDICINA CLÍNICA HOSPITALARIA 53754 CUIDADOS INTENSIVOS 5208 VENTILACIÓN MECÁNICA 37360 NEUMOLOGÍA 25628 Hardin, C. Corey 54283 22717 22650 Massachusetts NEJM Group NEJM12 The New England Journal of Medicine ESSALUD 0028-4793 ARTICULOS 2026-08-21 sqb 22858 22858