TY  - BOOK
AU  - Bhoj, Vijay G. 
AU  - Kaminski, María  
AU  - Zhao, Huiwu
AU  - Jackson, Kyle 
AU  - Wang, Wei 
AU  - Liu, Chengyang 
AU  - Montgomery, Robert A.  
AU  - Ali, Nicole  
AU  - Mangiola, Massimo 
AU  - Spitzer, Thomas R.  
AU  - Safa, Kassem 
TI  - Kidney transplantation in two highly sensitized candidates after CAR T-Cell therapy
KW  - ENFERMEDAD RENAL CRÓNICA
KW  - TRASPLANTE DE RIÑÓN
KW  - CIRUGÍA GENERAL
KW  - CÉLULAS T
KW  - TRASPLANTE
N2  - HLA sensitization poses a major challenge to kidney transplantation for patients with end-stage kidney disease, especially for highly sensitized candidates. Attempts at antibody elimination (desensitization) have had inconsistent efficacy and have often failed to produce sustained reductions in anti-HLA antibodies in patients with the highest level of sensitization (calculated panel-reactive antibody score, ≥99.9%). We now report the results for the safety run-in cohort of a multicenter phase 1 clinical study evaluating the safety and efficacy of combined CD19-targeted and B-cell maturation antigen (BCMA)–targeted chimeric antigen receptor (CAR) T cells in eliminating the cellular sources of preformed anti-HLA antibodies (ClinicalTrials.gov number, NCT06056102). Kidney transplantation was performed in two highly sensitized candidates after desensitization with the use of dual CAR T-cell therapy
ER  -