02780nam a2200325 4500 ESSALUD 20260819164758.0 ta t pe ||||| |||| 00| 0 spa d BMG eng Frat, Jean-Pierre Autor 54172 High-flow or standard oxygen in acute hypoxemic respiratory failure páginas: 2095-2106 Background: Data are needed on the effect of oxygen delivered through a high-flow nasal cannula, as compared with standard oxygen therapy, on intubation and mortality in patients with acute hypoxemic respiratory failure. Methods: In this multicenter, open-label trial, we randomly assigned patients who had acute hypoxemic respiratory failure to receive high-flow-oxygen or standard-oxygen therapy. All the patients had a ratio of the partial pressure of arterial oxygen to the fraction of inspired oxygen of 200 or less, a respiratory rate of more than 25 breaths per minute, and pulmonary infiltrate on chest imaging. The primary outcome was death by day 28. Results: A total of 1116 patients underwent randomization. Of these patients, 1110 (556 in the high-flow-oxygen group and 554 in the standard-oxygen group) were included in the analysis. Mortality at day 28 was 14.6% (in 81 of 556 patients) in the high-flow-oxygen group and 14.6% (in 81 of 554 patients) in the standard-oxygen group (difference, −0.05 percentage points; 95% confidence interval [CI], −4.21 to 4.10; P=0.98). The incidence of intubation by day 28 was 42.4% (in 236 of 556 patients) in the high-flow-oxygen group and 48.4% (in 268 of 554 patients) in the standard-oxygen group (difference, −5.93 percentage points; 95% CI, −11.78 to −0.08). Serious adverse events (cardiac arrest or pneumothorax) occurred during spontaneous breathing in 13 patients (2.3%) in the high-flow-oxygen group and in 6 patients (1.1%) in the standard-oxygen group. Conclusions: Among patients with acute hypoxemic respiratory failure, the use of oxygen delivered through a high-flow nasal cannula did not significantly reduce mortality at day 28. CUIDADOS INTENSIVOS 5208 MEDICINA DE URGENCIAS 53820 MEDICINA CLINICA HOSPITALARIA 53754 VENTILACION MECANICA 37360 NEUMOLOGÍA 25628 Quenot, Jean-Pierre 54173 Guitton, Christophe 54174 Coudroy, Rémi 54175 Gacouin, Arnaud 54176 Badie, Julio 54177 Demoule, Alexandre 54178 Contou, Damien 54179 22717 22648 Massachusetts NEJM Group NEJM011 The New England Journal of Medicine ESSALUD 0028-4793 ARTICULOS 2026-08-19 sqb 22834 22834