02614nam a2200301   4500001000800000005001700008007000300025008004100028040000800069041000800077100003000085245007200115300002500187520171600212650002401928650002601952650003401978650002502012650001702037700002402054700002502078700002202103700002102125700001802146700002502164700002002189773010302209ESSALUD20260819164758.0ta      t        pe ||||| |||| 00| 0 spa d  aBMG  aeng  aFrat, Jean-Pierre eAutor  aHigh-flow or standard oxygen in acute hypoxemic respiratory failure  apáginas: 2095-2106  aBackground: Data are needed on the effect of oxygen delivered through a high-flow nasal cannula, as compared with standard oxygen therapy, on intubation and mortality in patients with acute hypoxemic respiratory failure. Methods: In this multicenter, open-label trial, we randomly assigned patients who had acute hypoxemic respiratory failure to receive high-flow-oxygen or standard-oxygen therapy. All the patients had a ratio of the partial pressure of arterial oxygen to the fraction of inspired oxygen of 200 or less, a respiratory rate of more than 25 breaths per minute, and pulmonary infiltrate on chest imaging. The primary outcome was death by day 28. Results: A total of 1116 patients underwent randomization. Of these patients, 1110 (556 in the high-flow-oxygen group and 554 in the standard-oxygen group) were included in the analysis. Mortality at day 28 was 14.6% (in 81 of 556 patients) in the high-flow-oxygen group and 14.6% (in 81 of 554 patients) in the standard-oxygen group (difference, −0.05 percentage points; 95% confidence interval [CI], −4.21 to 4.10; P=0.98). The incidence of intubation by day 28 was 42.4% (in 236 of 556 patients) in the high-flow-oxygen group and 48.4% (in 268 of 554 patients) in the standard-oxygen group (difference, −5.93 percentage points; 95% CI, −11.78 to −0.08). Serious adverse events (cardiac arrest or pneumothorax) occurred during spontaneous breathing in 13 patients (2.3%) in the high-flow-oxygen group and in 6 patients (1.1%) in the standard-oxygen group. Conclusions: Among patients with acute hypoxemic respiratory failure, the use of oxygen delivered through a high-flow nasal cannula did not significantly reduce mortality at day 28.   aCUIDADOS INTENSIVOS  aMEDICINA DE URGENCIAS  aMEDICINA CLINICA HOSPITALARIA  aVENTILACION MECANICA  aNEUMOLOGÍA  aQuenot, Jean-Pierre  aGuitton, Christophe   aCoudroy, Rémi    aGacouin, Arnaud   aBadie, Julio   aDemoule, Alexandre    aContou, Damien 0 022717dMassachusetts NEJM GroupoNEJM011tThe New England Journal of Medicine wESSALUDx0028-4793