01960nam a2200265 4500 ESSALUD 20260805101217.0 ta t pe ||||| |||| 00| 0 spa d BMG eng Hegedüs, Laszlo 53915 Management of differentiated thyroid cancer páginas: 2340-2355 Modern risk-adapted management of thyroid cancer involves risk stratification as an active, dynamic process that begins with the detection of a thyroid nodule and continues throughout the clinical course of diagnosis, active surveillance or treatment, and follow-up. Rooted in clinicopathological staging, which can be further refined with the molecular risk characterization of the tumor, initial management plans are developed and modified over time on the basis of the natural history of the disease and the response to therapy. We present a clinical framework for therapeutic decision making that can be used to compare, contrast, and illustrate the relative risks, benefits, and patient preferences that are integral to the development of a personalized management plan. We examine examples of therapeutic decision making in active surveillance of low-risk papillary thyroid cancer, minimalist therapeutic management options for low- and intermediate-risk thyroid cancer, and systemic therapies for advanced thyroid cancer, showing how the therapeutic decision-making framework can be used to achieve informed consensus and management recommendations. MEDICINA DEL ADOLESCENTE 5533 CANCER INFANTIL 53916 HEMATOLOGÍA 7422 ONCOLOGÍA 12240 HEMATOLOGÍA 7422 Wirth, Lori J. 53917 Tuttle , R. Michael 53918 22717 22640 Massachusetts NEJM Group NEJM007 The New England Journal of Medicine ESSALUD 0028-4793 ARTICULOS 2026-08-03 SQB 22770 22770