02423nam a2200229   4500001000800000005001700008007000300025008004100028040000800069041000800077100003800085245007800123300002300201520169500224650002401919650003501943650002601978650003102004773011002035942003102145999001702176ESSALUD20260804164011.0ta      t        pe ||||| |||| 00| 0 spa d  aBMG  aeng  aSullivan, Nancy J. eAutor953765  aBundibugyo virus disease in 2026 — Clinical and public health responses  apáginas: 278-289  aBundibugyo virus is a relatively rare orthoebolavirus that has caused only two previously recognized disease outbreaks but remains capable of producing severe epidemic disease with substantial mortality. The 2026 outbreak of Bundibugyo virus disease in the Democratic Republic of Congo has highlighted persistent challenges in the detection of filovirus disease outbreaks, as well as in diagnosis, clinical management, and the public health response, particularly in resource-limited settings. As with other filovirus infections, effective control of the Bundibugyo virus disease outbreak depends on rapid identification of cases, laboratory confirmation of infection, isolation of cases, contact tracing, infection-prevention measures, protection of health care workers, and community engagement. Although no licensed vaccines or approved therapeutics specific to Bundibugyo virus disease are currently available, advances in supportive care have improved outcomes during recent filovirus disease outbreaks. Experimental evidence from studies involving nonhuman primates, serologic investigations with human samples, and monoclonal antibody research suggests that vaccines and therapeutics developed against Ebola virus may provide cross-protective activity against Bundibugyo virus. These observations support prototype-pathogen approaches to preparedness while underscoring the need for continued development of pathogen-specific countermeasures. The current outbreak reinforces the principle that a successful response to filovirus disease requires integration of medical countermeasures, clinical care, surveillance, diagnostics, and coordinated multinational public health operations.  aSALUD GLOBAL910472  aENFERMEDADES INFECCIOSAS96776  aSALUD PÚBLICA91652  aINFECCIONES VIRALES9537660 022717922636dMassachusetts NEJM GroupoNEJM003tThe New England Journal of Medicine wESSALUDx0028-4793  cARTICULOSe2026-07-31zSQB  c22741d22741