02797nam a2200289   4500001000800000005001700008007000300025008004100028040000800069041000800077100003300085245006900118300002100187520186400208650003302072650003202105650003202137700003402169700003002203700002902233700002502262700003402287700002802321773011002349942003102459999001702490ESSALUD20260804122304.0ta      t        pe ||||| |||| 00| 0 spa d  aBMG  aeng  aDaemen, Joost eAutor953647  aAngiography-based physiology to guide coronary revascularization  apáginas: 20-31  aBackground: Current society guidelines recommend physiological assessment of intermediate coronary lesions to guide revascularization. Data regarding revascularization guided by vessel fractional flow reserve (vFFR), derived from three-dimensional quantitative coronary angiography without the need for a pressure wire or hyperemic agent, as compared with pressure-wire–based fractional flow reserve (FFR), are lacking.
Methods: We conducted an international, open-label, randomized, noninferiority trial at 37 sites in Europe. Patients with intermediate coronary-artery lesions (diameter stenosis of 30 to 80%) who presented with chronic or acute coronary syndromes were randomly assigned in a 1:1 ratio to undergo either vFFR-guided or FFR-guided revascularization of the intermediate coronary-artery lesions. The primary end point was a composite of death from any cause, any myocardial infarction, or any revascularization at 1 year. The noninferiority margin was 3.0 percentage points.
Results: The primary end point was assessed in 1116 patients in the vFFR group and 1095 in the FFR group. The mean age of the patients was 67 years, 24.3% were women, 18.7% presented with an acute coronary syndrome, and 26.6% had diabetes mellitus. At 1 year, a primary end-point event had occurred in 80 patients (Kaplan–Meier estimate, 7.5%) in the vFFR group and in 79 patients (Kaplan–Meier estimate, 7.5%) in the FFR group (risk difference, −0.02 percentage points; 95% confidence interval, −2.25 to 2.21; P=0.004 for noninferiority). The incidence of serious adverse events appeared to be similar in the two groups.
Conclusions: Among patients with intermediate coronary lesions, vFFR-guided revascularization was noninferior to FFR-guided revascularization with respect to a composite of death, myocardial infarction, or revascularization at 1 year. 
  aCARDIOLOGÍA GENERAL953638  aENFERMEDAD CORONARIA914895  aINFARTO DE MIOCARDIO913202  aVan der Eijk, Jari A. 953648  aBarbierato, Marco 953649  aByrne, Robert A. 938050  aCanova, Paolo953650  aDe Maria, Giovanni L. 953651  aVan Belle, Eric 9536520 022717922634dMassachusetts NEJM GroupoNEJM001tThe New England Journal of Medicine wESSALUDx0028-4793  cARTICULOSe2026-07-31zsqb  c22722d22722