Combined oral ivermectin and 5% permethrin cream to treat severe scabies (Registro nro. 22926)
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| 000 -Cabecera | |
|---|---|
| Campo de control interno | 02813nam a2200301 4500 |
| 001 - Número de control | |
| control field | ESSALUD |
| 005 - Fecha y hora de la última transacción | |
| Campo de control | 20260903142646.0 |
| 007 - Tipo material - Descripcion fisica - info general | |
| Tipo material - Descripcion fisica - info general | ta |
| 008 - Elementos de Longitud Fija - Información General | |
| Elementos de Longitud Fija - Información | t pe ||||| |||| 00| 0 spa d |
| 040 ## - Origen de la Catalogación | |
| Origen de la Catalogación | BMG |
| 041 ## - Idioma | |
| Idioma | eng |
| 100 ## - Autor | |
| Autor | Bernigaud, Charlotte |
| Rol del Autor | Autor |
| 9 (RLIN) | 54546 |
| 245 ## - Titulo | |
| Titulo | Combined oral ivermectin and 5% permethrin cream to treat severe scabies |
| 300 ## - Páginas | |
| Paginación | páginas: 1814-1823 |
| 520 ## - Resumen | |
| Resumen | Background: Severe scabies, a rare parasitic skin disease characterized by abundant skin mites, may be life-threatening and poses public health concerns worldwide. A combination of standard-dose oral ivermectin and topical scabicides is recommended for treatment. However, data from randomized clinical trials are lacking, and the probability of cure is uncertain. Ivermectin at higher doses has been effective in the treatment of some parasitic diseases. Methods: We conducted a blinded randomized trial involving adults with severe scabies (i.e., profuse or crusted), as confirmed by parasitologic or dermoscopic assessment. The patients were assigned in a 1:1 ratio to receive oral ivermectin (to be taken with food) at a dose of 400 μg per kilogram of body weight (higher-dose group) or 200 μg per kilogram (standard-dose group) on days 0, 7, and 14, combined with head-to-toe application of 5% permethrin cream on days 0 and 7 and daily application (as recommended) of an emollient cream. The primary end point was cure of severe scabies, which was defined as the absence of mites and mite-related products (i.e., eggs and feces), as confirmed by parasitologic or dermoscopic assessment on days 18 and 21, and the absence of active clinical lesions on physical examination on day 28. Results: A total of 132 patients (66 in each group) were included in the main analysis. Cure was observed in 75% of the patients in the higher-dose group and in 82% of those in the standard-dose group (odds ratio for cure, 0.64; 95% confidence interval, 0.25 to 1.67). No safety issues were identified. Conclusions: Among adults, the 400-μg-per-kilogram dose of ivermectin plus 5% permethrin cream was not superior to the standard 200-μg-per-kilogram dose of ivermectin plus 5% permethrin cream in curing severe scabies. |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | DERMATOLOGÍA GENERAL |
| 9 (RLIN) | 54449 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | SALUD GLOBAL |
| 9 (RLIN) | 10472 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | ENFERMEDADES INFECCIOSAS GENERALES |
| 9 (RLIN) | 54087 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | INFECCIONES PARASITARIAS |
| 9 (RLIN) | 54373 |
| 700 ## - Autor Personal | |
| Autor Personal | Do-Pham, Giao |
| 9 (RLIN) | 54547 |
| 700 ## - Autor Personal | |
| Autor Personal | Guichard, Elie |
| 9 (RLIN) | 54548 |
| 700 ## - Autor Personal | |
| Autor Personal | Beylot-Barry, Marie |
| 9 (RLIN) | 54549 |
| 700 ## - Autor Personal | |
| Autor Personal | Goujon, Elisa |
| 9 (RLIN) | 54550 |
| 700 ## - Autor Personal | |
| Autor Personal | Isnard, Camille |
| 9 (RLIN) | 54551 |
| 700 ## - Autor Personal | |
| Autor Personal | Beneton, Nathalie |
| 9 (RLIN) | 54552 |
| 773 0# - Revista (Relacion con el numero) | |
| Host Biblionumber | 22717 |
| Host Itemnumber | 22676 |
| Ciudad, Editorial | Massachusetts NEJM Group |
| Codigo barras item/ejemplar | NEJM015 |
| Titulo de la Revista | The New England Journal of Medicine |
| Número de control de registro | ESSALUD |
| ISSN | 0028-4793 |
| 942 ## - Elementos de Koha | |
| Tipo de Documento | Artículos |
| Fecha procesamiento | 2026-08-31 |
| Catalogador | sqb |
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