Azithromycin for preschoolers with wheezing in the emergency department (Registro nro. 22852)
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| 000 -Cabecera | |
|---|---|
| Campo de control interno | 03547nam a2200337 4500 |
| 001 - Número de control | |
| control field | ESSALUD |
| 005 - Fecha y hora de la última transacción | |
| Campo de control | 20260821115150.0 |
| 007 - Tipo material - Descripcion fisica - info general | |
| Tipo material - Descripcion fisica - info general | ta |
| 008 - Elementos de Longitud Fija - Información General | |
| Elementos de Longitud Fija - Información | t pe ||||| |||| 00| 0 spa d |
| 040 ## - Origen de la Catalogación | |
| Origen de la Catalogación | BMG |
| 041 ## - Idioma | |
| Idioma | eng |
| 100 ## - Autor | |
| Autor | Denninghoff, Kurt R. |
| Rol del Autor | Autor |
| 9 (RLIN) | 54246 |
| 245 ## - Titulo | |
| Titulo | Azithromycin for preschoolers with wheezing in the emergency department |
| 300 ## - Páginas | |
| Paginación | páginas: 753-764 |
| 520 ## - Resumen | |
| Resumen | Background: Wheezing illnesses are a leading cause of hospitalization for preschool-age children and are frequently treated with antibiotics. Observational studies have shown more frequent isolation of three pathogenic bacteria (Streptococcus pneumoniae, Moraxella catarrhalis, and Haemophilus influenzae) from nasopharyngeal samples from children with recurrent episodes of wheezing than from those without such illnesses. Methods: In this multicenter trial, we randomly assigned patients 18 to 59 months of age who presented to an emergency department with a moderate-to-severe episode of wheezing to receive azithromycin once daily at a dose of 12 mg per kilogram of body weight or matching placebo for 5 days. The primary outcome was the sum of scores on the Asthma Flare-up Diary for Young Children (ADYC) over 5 days. Primary-outcome scores could range from 5 to 35, with higher scores indicating more severe wheezing-related symptoms. Efficacy was assessed separately in patients who tested positive for pathogenic bacteria (the positive cohort) and in those who tested negative (the negative cohort). Secondary outcomes were length of stay in the emergency department, length of hospital stay, and return emergency department visits or hospitalizations within 72 hours. Bacterial clearance and antimicrobial resistance were measured at follow-up visits 1 to 3 weeks after randomization. Results: Among 840 patients who underwent randomization, 521 tested positive for pathogenic bacteria. The trial was stopped for futility by the data and safety monitoring board after a planned interim analysis. ADYC scores did not differ significantly between the azithromycin and placebo groups in either the positive cohort (median, 9.59 [interquartile range, 7.29 to 12.60] vs. 9.72 [interquartile range, 7.66 to 12.17]; P=0.70) or the negative cohort (median, 9.30 [interquartile range, 6.97 to 11.62] vs. 9.10 [interquartile range, 7.19 to 11.45]; P=0.69). In the positive cohort, bacterial clearance was 58.7% in the azithromycin group and 11.4% in the placebo group. Secondary outcomes appeared to be similar in the two groups for both cohorts, as did the development of bacterial resistance and the incidence of adverse events. Conclusions: Azithromycin did not lead to a greater reduction in the severity of wheezing-related symptoms than placebo in preschool-age children who presented to the emergency department with moderate-to-severe acute wheezing. |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | ALERGIA |
| 9 (RLIN) | 7055 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | ASMA |
| 9 (RLIN) | 9753 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | NEUMOLOGÍA |
| 9 (RLIN) | 25628 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | CUIDADOS INTENSIVOS |
| 9 (RLIN) | 5208 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | ENFERMEDADES INFANTILES |
| 9 (RLIN) | 53890 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | MEDICINA DE URGENCIAS GENERAL |
| 9 (RLIN) | 54078 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | PEDIATRÍA GENERAL |
| 9 (RLIN) | 54247 |
| 700 ## - Autor Personal | |
| Autor Personal | Casper, T. Charles |
| 9 (RLIN) | 54248 |
| 700 ## - Autor Personal | |
| Autor Personal | Zorc, Joseph J. |
| 9 (RLIN) | 54249 |
| 700 ## - Autor Personal | |
| Autor Personal | Ruddy, Richard M. |
| 9 (RLIN) | 54250 |
| 700 ## - Autor Personal | |
| Autor Personal | Satola, Sarah |
| 9 (RLIN) | 54251 |
| 700 ## - Autor Personal | |
| Autor Personal | Wendt, Wendi-Jo |
| 9 (RLIN) | 54252 |
| 700 ## - Autor Personal | |
| Autor Personal | Morris, Claudia R. |
| 9 (RLIN) | 54253 |
| 773 0# - Revista (Relacion con el numero) | |
| Host Biblionumber | 22717 |
| Host Itemnumber | 22650 |
| Ciudad, Editorial | Massachusetts NEJM Group |
| Codigo barras item/ejemplar | NEJM12 |
| Titulo de la Revista | The New England Journal of Medicine |
| Número de control de registro | ESSALUD |
| ISSN | 0028-4793 |
| 942 ## - Elementos de Koha | |
| Tipo de Documento | Artículos |
| Fecha procesamiento | 2026-08-21 |
| Catalogador | sqb |
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