Neuroepithelial tumor with AAV integration after intracisternal magna vector delivery (Registro nro. 22843)
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| 000 -Cabecera | |
|---|---|
| Campo de control interno | 01870nam a2200337 4500 |
| 001 - Número de control | |
| control field | ESSALUD |
| 005 - Fecha y hora de la última transacción | |
| Campo de control | 20260820162144.0 |
| 007 - Tipo material - Descripcion fisica - info general | |
| Tipo material - Descripcion fisica - info general | ta |
| 008 - Elementos de Longitud Fija - Información General | |
| Elementos de Longitud Fija - Información | t pe ||||| |||| 00| 0 spa d |
| 040 ## - Origen de la Catalogación | |
| Origen de la Catalogación | BMG |
| 041 ## - Idioma | |
| Idioma | eng |
| 100 ## - Autor | |
| Autor | Ahrens-Nicklas, Rebecca C. |
| Rol del Autor | Autor |
| 9 (RLIN) | 54204 |
| 245 ## - Titulo | |
| Titulo | Neuroepithelial tumor with AAV integration after intracisternal magna vector delivery |
| 300 ## - Páginas | |
| Paginación | páginas: 2126-2133 |
| 520 ## - Resumen | |
| Resumen | Recombinant adeno-associated virus (AAV) vectors are predominantly nonintegrating, but rare genomic integration events have been associated with oncogenesis in neonatal murine models. Here we report a case of a neuroepithelial tumor that developed in a 5-year-old boy with severe mucopolysaccharidosis type I (MPSI, Hurler subtype) 4 years after intracisternal magna administration of AAV serotype 9 gene therapy. The patient underwent successful resection of the primary tumor. Postoperatively, he has continued to have advanced cognitive function for his age, a finding that indicates mitigation of MPSI. Molecular analysis of the tumor showed clonal integration of rearranged AAV vector elements into the gene PLAG1 and expression of a chimeric AAV-PLAG1 transcript. |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | TUMOR CEREBRAL |
| 9 (RLIN) | 54205 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | ENFERMEDADES INFANTILES |
| 9 (RLIN) | 53890 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | GENÉTICA GENERAL |
| 9 (RLIN) | 54107 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | NEUROLOGÍA |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | NEUROCIRUGÍA |
| 9 (RLIN) | 7782 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | PEDIATRÍA |
| 9 (RLIN) | 6401 |
| 700 ## - Autor Personal | |
| Autor Personal | Kotch, Chelsea |
| 9 (RLIN) | 54206 |
| 700 ## - Autor Personal | |
| Autor Personal | Roche, Aoife M. |
| 9 (RLIN) | 54207 |
| 700 ## - Autor Personal | |
| Autor Personal | Everett, John K. |
| 9 (RLIN) | 54208 |
| 700 ## - Autor Personal | |
| Autor Personal | Reddy, Shantan |
| 9 (RLIN) | 54209 |
| 700 ## - Autor Personal | |
| Autor Personal | Santi, Mariarita |
| 9 (RLIN) | 54210 |
| 700 ## - Autor Personal | |
| Autor Personal | Madsen, Peter J. |
| 9 (RLIN) | 54211 |
| 700 ## - Autor Personal | |
| Autor Personal | Martos-Rus, Cristina |
| 9 (RLIN) | 54212 |
| 773 0# - Revista (Relacion con el numero) | |
| Host Biblionumber | 22717 |
| Host Itemnumber | 22648 |
| Ciudad, Editorial | Massachusetts NEJM Group |
| Codigo barras item/ejemplar | NEJM011 |
| Titulo de la Revista | The New England Journal of Medicine |
| Número de control de registro | ESSALUD |
| ISSN | 0028-4793 |
| 942 ## - Elementos de Koha | |
| Tipo de Documento | Artículos |
| Fecha procesamiento | 2026-08-20 |
| Catalogador | sqb |
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