Kidney transplantation in two highly sensitized candidates after CAR T-Cell therapy (Registro nro. 22842)
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| 000 -Cabecera | |
|---|---|
| Campo de control interno | 02084nam a2200361 4500 |
| 001 - Número de control | |
| control field | ESSALUD |
| 005 - Fecha y hora de la última transacción | |
| Campo de control | 20260820161112.0 |
| 007 - Tipo material - Descripcion fisica - info general | |
| Tipo material - Descripcion fisica - info general | ta |
| 008 - Elementos de Longitud Fija - Información General | |
| Elementos de Longitud Fija - Información | t pe ||||| |||| 00| 0 spa d |
| 040 ## - Origen de la Catalogación | |
| Origen de la Catalogación | BMG |
| 041 ## - Idioma | |
| Idioma | eng |
| 100 ## - Autor | |
| Autor | Bhoj, Vijay G. |
| Rol del Autor | Autor |
| 9 (RLIN) | 54193 |
| 245 ## - Titulo | |
| Titulo | Kidney transplantation in two highly sensitized candidates after CAR T-Cell therapy |
| 300 ## - Páginas | |
| Paginación | páginas: 2117-2125 |
| 520 ## - Resumen | |
| Resumen | HLA sensitization poses a major challenge to kidney transplantation for patients with end-stage kidney disease, especially for highly sensitized candidates. Attempts at antibody elimination (desensitization) have had inconsistent efficacy and have often failed to produce sustained reductions in anti-HLA antibodies in patients with the highest level of sensitization (calculated panel-reactive antibody score, ≥99.9%). We now report the results for the safety run-in cohort of a multicenter phase 1 clinical study evaluating the safety and efficacy of combined CD19-targeted and B-cell maturation antigen (BCMA)–targeted chimeric antigen receptor (CAR) T cells in eliminating the cellular sources of preformed anti-HLA antibodies (ClinicalTrials.gov number, NCT06056102). Kidney transplantation was performed in two highly sensitized candidates after desensitization with the use of dual CAR T-cell therapy. |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | ENFERMEDAD RENAL CRÓNICA |
| 9 (RLIN) | 32213 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | TRASPLANTE DE RIÑÓN |
| 9 (RLIN) | 13898 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | CIRUGÍA GENERAL |
| 9 (RLIN) | 44496 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | CÉLULAS T |
| 9 (RLIN) | 54097 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | TRASPLANTE |
| 9 (RLIN) | 7847 |
| 700 ## - Autor Personal | |
| Autor Personal | Kaminski, María |
| 9 (RLIN) | 54194 |
| 700 ## - Autor Personal | |
| Autor Personal | Zhao, Huiwu |
| 9 (RLIN) | 54195 |
| 700 ## - Autor Personal | |
| Autor Personal | Jackson, Kyle |
| 9 (RLIN) | 54196 |
| 700 ## - Autor Personal | |
| Autor Personal | Wang, Wei |
| 9 (RLIN) | 54197 |
| 700 ## - Autor Personal | |
| Autor Personal | Liu, Chengyang |
| 9 (RLIN) | 54198 |
| 700 ## - Autor Personal | |
| Autor Personal | Montgomery, Robert A. |
| 9 (RLIN) | 54199 |
| 700 ## - Autor Personal | |
| Autor Personal | Ali, Nicole |
| 9 (RLIN) | 54200 |
| 700 ## - Autor Personal | |
| Autor Personal | Mangiola, Massimo |
| 9 (RLIN) | 54201 |
| 700 ## - Autor Personal | |
| Autor Personal | Spitzer, Thomas R. |
| 9 (RLIN) | 54202 |
| 700 ## - Autor Personal | |
| Autor Personal | Safa, Kassem |
| 9 (RLIN) | 54203 |
| 773 0# - Revista (Relacion con el numero) | |
| Host Biblionumber | 22717 |
| Host Itemnumber | 22648 |
| Ciudad, Editorial | Massachusetts NEJM Group |
| Codigo barras item/ejemplar | NEJM011 |
| Titulo de la Revista | The New England Journal of Medicine |
| Número de control de registro | ESSALUD |
| ISSN | 0028-4793 |
| 942 ## - Elementos de Koha | |
| Tipo de Documento | Artículos |
| Fecha procesamiento | 2026-08-20 |
| Catalogador | sqb |
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