Sirolimus-Coated Balloon Angioplasty for Infrainguinal Artery Disease (Registro nro. 22814)
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| 000 -Cabecera | |
|---|---|
| Campo de control interno | 03247nam a2200277 4500 |
| 001 - Número de control | |
| control field | ESSALUD |
| 007 - Tipo material - Descripcion fisica - info general | |
| Tipo material - Descripcion fisica - info general | ta |
| 008 - Elementos de Longitud Fija - Información General | |
| Elementos de Longitud Fija - Información | t pe ||||| |||| 00| 0 spa d |
| 040 ## - Origen de la Catalogación | |
| Origen de la Catalogación | BMG |
| 041 ## - Idioma | |
| Idioma | eng |
| 100 ## - Autor | |
| Autor | Barco, Stefano |
| Rol del Autor | Autor |
| 9 (RLIN) | 54060 |
| 245 ## - Titulo | |
| Titulo | Sirolimus-Coated Balloon Angioplasty for Infrainguinal Artery Disease |
| 300 ## - Páginas | |
| Paginación | páginas: 561-570 |
| 520 ## - Resumen | |
| Resumen | Background: Whether sirolimus-coated balloon angioplasty for infrainguinal artery disease reduces the incidence of major adverse limb events remains unknown. Methods: In this prospective, open-label, noninferiority trial with a prespecified sequential testing strategy for superiority and blinded outcome adjudication, we randomly assigned patients with infrainguinal artery disease in a 1:1 ratio to undergo angioplasty with a sirolimus-coated balloon or with an uncoated balloon. The primary outcome was a composite of unplanned major amputation affecting the target limb or endovascular or surgical revascularization of the target lesion for critical limb ischemia within 1 year after randomization. The key secondary outcome was a composite of any unplanned amputation affecting the target limb or revascularization of the target lesion for critical or noncritical limb ischemia within 1 year after randomization. The noninferiority margin was 5 percentage points. The primary safety outcome was death from any cause within 1 year after randomization. Results: A total of 1252 patients were enrolled in the trial: 626 patients were assigned to the sirolimus-coated–balloon group and 626 to the uncoated-balloon group. The median age of the patients was 75 years, and 35.1% were women. A primary-outcome event occurred in 55 patients (8.8%) in the sirolimus-coated–balloon group and in 94 patients (15.0%) in the uncoated-balloon group (median unbiased estimate of risk difference, −4.9 percentage points; 95% confidence interval [CI], −8.5 to −1.3; P<0.001 for noninferiority; P=0.009 for superiority); a key secondary-outcome event occurred in 144 patients (23.0%) and 193 patients (30.8%), respectively (risk difference, −7.8 percentage points; 95% CI, −12.7 to −2.9; P=0.002). Death occurred in 74 patients (11.8%) in the sirolimus-coated–balloon group and in 80 patients (12.8%) in the uncoated-balloon group (risk difference, −1.0 percentage points; 95% CI, −4.6 to 2.7; P=0.67). The incidence of adverse events appeared to be similar in the two groups. Conclusions: Among patients with infrainguinal artery disease undergoing endovascular treatment, angioplasty with sirolimus-coated balloons led to a lower incidence of major adverse limb events at 1 year than angioplasty with uncoated balloons. |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | CARDIOLOGÍA |
| 9 (RLIN) | 11301 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | ENFERMEDAD ARTERIAL PERIFÉRICA AORTICA |
| 9 (RLIN) | 54061 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | ANGIOPLASTIA |
| 9 (RLIN) | 37212 |
| 700 ## - Autor Personal | |
| Autor Personal | Engelberger, Rolf P. |
| 9 (RLIN) | 54062 |
| 700 ## - Autor Personal | |
| Autor Personal | Held, Ulrike |
| 9 (RLIN) | 54063 |
| 700 ## - Autor Personal | |
| Autor Personal | Fumagalli, Riccardo M. |
| 9 (RLIN) | 54064 |
| 700 ## - Autor Personal | |
| Autor Personal | Grigorean, Alexandru |
| 9 (RLIN) | 54065 |
| 700 ## - Autor Personal | |
| Autor Personal | Hayoz, Daniel |
| 9 (RLIN) | 54066 |
| 700 ## - Autor Personal | |
| Autor Personal | Münger, Mario |
| 9 (RLIN) | 54067 |
| 773 0# - Revista (Relacion con el numero) | |
| Host Biblionumber | 22717 |
| Host Itemnumber | 22644 |
| Ciudad, Editorial | Massachusetts NEJM Group |
| Codigo barras item/ejemplar | NEJM009 |
| Titulo de la Revista | The New England Journal of Medicine |
| Número de control de registro | ESSALUD |
| ISSN | 0028-4793 |
| 942 ## - Elementos de Koha | |
| Tipo de Documento | Artículos |
| Fecha procesamiento | 2026-08-14 |
| Catalogador | SQB |
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