Interleukin-10 autoantibodies and HLA-DRB1*01:03 in inflammatory bowel disease (Registro nro. 22776)
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| 000 -Cabecera | |
|---|---|
| Campo de control interno | 02873nam a2200301 4500 |
| 001 - Número de control | |
| control field | ESSALUD |
| 005 - Fecha y hora de la última transacción | |
| Campo de control | 20260805113858.0 |
| 007 - Tipo material - Descripcion fisica - info general | |
| Tipo material - Descripcion fisica - info general | ta |
| 008 - Elementos de Longitud Fija - Información General | |
| Elementos de Longitud Fija - Información | t pe ||||| |||| 00| 0 spa d |
| 040 ## - Origen de la Catalogación | |
| Origen de la Catalogación | BMG |
| 041 ## - Idioma | |
| Idioma | eng |
| 100 ## - Autor | |
| Autor | Gharahdaghi, Nima |
| Rol del Autor | Autor |
| 9 (RLIN) | 53934 |
| 245 ## - Titulo | |
| Titulo | Interleukin-10 autoantibodies and HLA-DRB1*01:03 in inflammatory bowel disease |
| 300 ## - Páginas | |
| Paginación | páginas: 2212-2222 |
| 520 ## - Resumen | |
| Resumen | Background: Neutralizing autoantibodies against interleukin-10 can result in a phenocopy of monogenic defects of interleukin-10 signaling in children and may be associated with inflammatory bowel disease (IBD). The allele HLA-DRB1*01:03 is the strongest genetic risk factor for ulcerative colitis.<br/>Methods: We used a cellular interleukin-10 reporter assay and a confirmatory competitive enzyme-linked immunosorbent assay to assess neutralizing interleukin-10 autoantibodies in serum samples obtained from patients with IBD in the Oxford and U.K. IBD BioResource cohorts and from persons without IBD (controls). An in vitro cytokine-release bioassay was performed in a subgroup of patients to assess interleukin-10, interleukin-23, interleukin-1β, tumor necrosis factor, and interleukin-6. We performed HLA association analysis using imputation and high-resolution sequencing.<br/>Results: Interleukin-10–neutralizing autoantibodies were detected in 173 of 4909 patients with IBD (3.5%; 95% confidence interval [CI], 3.0 to 4.1) and in none of 1006 controls (P<0.001). High anti–interleukin-10 activity in serum was associated with a reduction in detectable interleukin-10 and with an exaggerated proinflammatory cytokine response, consistent with functional neutralization of interleukin-10 signaling. Anti–interleukin-10 seropositivity was strongly associated with HLA-DRB1*01:03 on the basis of imputed data from the Oxford cohort (odds ratio, 50.0; 95% CI, 16.4 to 152.3; P=6.14×10−12) and the U.K. IBD BioResource cohort (odds ratio, 24.7; 95% CI, 14.5 to 42.1; P=6.20×10−32) and in a high-resolution sequencing analysis of data from the Oxford cohort (odds ratio, 29.5; 95% CI, 12.2 to 71.1; P=4.85×10−14).<br/>Conclusions: Neutralizing interleukin-10 autoantibodies were present in a subgroup of patients with IBD and were strongly associated with HLA-DRB1*01:03.<br/> |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | ALERGIA |
| 9 (RLIN) | 7055 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | ENFERMEDAD AUTOINMUNE |
| 9 (RLIN) | 53665 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | GENETICA |
| 9 (RLIN) | 1105 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | GASTROENTEROLOGÍA |
| 9 (RLIN) | 12562 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | ENFERMEDAD INFLAMATORIA INTESTINAL |
| 9 (RLIN) | 53935 |
| 700 ## - Autor Personal | |
| Autor Personal | Yeh, Pai-Jui |
| 9 (RLIN) | 53936 |
| 700 ## - Autor Personal | |
| Autor Personal | Cerón-Gutiérrez, Lourdes |
| 9 (RLIN) | 53937 |
| 700 ## - Autor Personal | |
| Autor Personal | Griffin, Helen |
| 9 (RLIN) | 53938 |
| 700 ## - Autor Personal | |
| Autor Personal | Gordon, Hannah |
| 9 (RLIN) | 53939 |
| 700 ## - Autor Personal | |
| Autor Personal | Jayamanne, Chamara |
| 9 (RLIN) | 53940 |
| 773 0# - Revista (Relacion con el numero) | |
| Host Biblionumber | 22717 |
| Host Itemnumber | 22641 |
| Ciudad, Editorial | Massachusetts NEJM Group |
| Codigo barras item/ejemplar | NEJM008 |
| Titulo de la Revista | The New England Journal of Medicine |
| Número de control de registro | ESSALUD |
| ISSN | 0028-4793 |
| 942 ## - Elementos de Koha | |
| Tipo de Documento | Artículos |
| Fecha procesamiento | 2026-08-03 |
| Catalogador | SQB |
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