Stemness as the engine of checkpoint durability (Registro nro. 22772)
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| Campo de control interno | 01624nam a2200241 4500 |
| 001 - Número de control | |
| control field | ESSALUD |
| 005 - Fecha y hora de la última transacción | |
| Campo de control | 20260805102227.0 |
| 007 - Tipo material - Descripcion fisica - info general | |
| Tipo material - Descripcion fisica - info general | ta |
| 008 - Elementos de Longitud Fija - Información General | |
| Elementos de Longitud Fija - Información | t pe ||||| |||| 00| 0 spa d |
| 040 ## - Origen de la Catalogación | |
| Origen de la Catalogación | BMG |
| 041 ## - Idioma | |
| Idioma | eng |
| 100 ## - Autor | |
| Autor | Hotchkiss, Richard S. |
| Rol del Autor | Autor |
| 9 (RLIN) | 53924 |
| 245 ## - Titulo | |
| Titulo | Stemness as the engine of checkpoint durability |
| 300 ## - Páginas | |
| Paginación | páginas: 2374-2377 |
| 520 ## - Resumen | |
| Resumen | Checkpoint inhibitors have transformed cancer therapy, with 250,000 to 400,000 patients treated annually in the United States. By blocking programmed cell death protein 1 (PD-1) or its ligand (PD-L1), checkpoint inhibitors suppress inhibitory signals that restrain T-cell activation, thereby restoring antitumor immunity. Despite early and sometimes dramatic responses, clinical benefits often wane. Retrospective analyses of checkpoint-inhibitor rechallenge show lower response rates and diminished durability as compared with initial treatment. These observations lead to the question: can prolonged or intensified PD-1 or PD-L1 blockade paradoxically compromise the long-term immune fitness required for sustained tumor control? A recent study by Hor et al. suggests that it does and provides a mechanistic framework that may reshape how checkpoint inhibitors are deployed and their durability extended. |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | CANCER |
| 9 (RLIN) | 1231 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | GENÉTICA |
| 9 (RLIN) | 1105 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | HEMATOLOGÍA |
| 9 (RLIN) | 7422 |
| 650 ## - Temas - Descriptores | |
| Temas - Descriptores | INMUNIDAD |
| 9 (RLIN) | 38590 |
| 700 ## - Autor Personal | |
| Autor Personal | DiPersio, John F. |
| 9 (RLIN) | 53925 |
| 773 0# - Revista (Relacion con el numero) | |
| Host Biblionumber | 22717 |
| Host Itemnumber | 22640 |
| Ciudad, Editorial | Massachusetts NEJM Group |
| Codigo barras item/ejemplar | NEJM007 |
| Titulo de la Revista | The New England Journal of Medicine |
| Número de control de registro | ESSALUD |
| ISSN | 0028-4793 |
| 942 ## - Elementos de Koha | |
| Tipo de Documento | Artículos |
| Fecha procesamiento | 2026-08-03 |
| Catalogador | SQB |
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